Facets of language performance in early-onset and late-onset Alzheimer's disease dementia.

ABSTRACT:

Introduction

Early-onset Alzheimer's disease dementia (EOAD) is characterized by more pronounced cognitive decline than late-onset AD dementia (LOAD). Characteristic performance in spoken language remains undefined.

Method

A cross-sectional analysis of 1189 people with EOAD and 4646 with LOAD from the National Alzheimer's Coordinating Center (NACC) was conducted.

Result

Based on data from their first NACC visit with AD, there was considerable heterogeneity in language performance across people with EOAD and LOAD. The distribution of naming ability was similar across these groups. On average, people with LOAD performed better than those with EOAD in category fluency, letter fluency, and spoken lexical retrieval, and had lower Clinical Dementia Rating (CDR) Language sco

SUBMITTER: Gallee J 

PROVIDER: S-EPMC12458901 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature