Early life gut microbial and metabolic shifts reflected in stool consistency- a gut transit time proxy.

ABSTRACT: Transit time, fluid intake, diet, and overall gut health all influence stool consistency. However, the relationships between the gut microbiota, metabolome (microbial metabolites), and stool consistency in infants and young children remain poorly understood. In this study, we analyzed the microbiota and metabolome of 618 stool samples from children aged 2.5 months (n = 360), 6 months (n = 229), 14 months (n = 274), and 30 months (n = 169) from the FinnBrain Birth Cohort Study, correlating these data with stool water content and parent-reported stool consistency. We found that breastfeeding had the strongest association with both stool consistency and fecal water content. We observed that the concentrations of newly discovered microbial bile acid amidates were associated with constipation a

SUBMITTER: Aatsinki AK 

PROVIDER: S-EPMC12458959 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature