The effect of blood viscosity on shear-induced hemolysis using a magnetically levitated shearing device.

ABSTRACT:

Introduction

Blood contacting medical devices, including rotary blood pumps, can cause shear-induced blood damage that may lead to adverse effects in patients. Due in part to an inadequate understanding of how cell-scale fluid mechanics impact red blood cell membrane deformation and damage, there is currently not a uniformly accepted engineering model for predicting blood damage caused by complex flow fields within ventricular assist devices (VADs).

Methods

We empirically investigated hemolysis in a magnetically levitated axial Couette flow device typical of a rotary VAD. The device is able to accurately control the shear rate and exposure time experienced by blood and to minimize the effects of other uncharacterized stresses. Using this device, we explored the effects of bo

SUBMITTER: Krisher JA 

PROVIDER: S-EPMC12458991 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature