Chemical Probes that Target a Dissociative LuxR-Type Quorum Sensing Receptor in Gram-Negative Bacteria.

ABSTRACT: Quorum sensing (QS) allows bacteria to respond to changes in cell density and participate in collective behaviors. Interfering with QS could provide a strategy to block pathogenicity, reduce biofouling, and support biotechnology. Many common Gram-negative bacteria use LuxR-type QS receptors that regulate gene transcription in response to N-acyl l-homoserine lactone (AHL) signals. The most-studied LuxR-type receptors operate via an associative mechanism, i.e., they dimerize and associate with DNA upon ligand binding. In contrast, members of the less-studied class of dissociative LuxR-type receptors bind DNA as dimers in the absence of a ligand and dissociate from DNA upon ligand binding. Few chemical tools to modulate dissociative receptor activity are known. Such probes could provid

SUBMITTER: Stoutland IM 

PROVIDER: S-EPMC12459020 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature