Clinical Significance of Plasma and Peripheral Blood Mononuclear Cell EBV-DNA in Lymphoma.

ABSTRACT:

Background

Epstein Barr virus (EBV) is a ubiquitous virus that establishes latent infection in the host and plays a critical role in the development and prognosis of lymphomas. The presence of EBV-DNA in peripheral blood is a widely used tumor marker. However, there is no consensus on the preferred blood compartment for EBV-DNA testing.

Methods

We retrospectively analyzed data from 256 lymphoma patients, including 21 with Hodgkin lymphoma, 96 with B-cell lymphoma, and 139 with T-cell or NK/T-cell lymphoma. Complete matched PBMC and plasma EBV-DNA datasets were available, allowing correlation analysis and assessment of their respective clinical significance.

Results

Detectable pretreatment EBV-DNA in either plasma or PBMCs was significantly associated with worse surviv

SUBMITTER: Wang L 

PROVIDER: S-EPMC12459219 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature