Exploring the anti-microbial potential of benzylated imidazolium salts: synthesis, docking studies, and biological evaluation.

ABSTRACT: Dibenzyl methyl-substituted imidazolium salts were synthesized from readily available starting materials using conventional methods. Initially, benzyl bromide derivatives were employed to alkylate 2-methyl-5-nitroimidazole under reflux conditions, yielding mono-, di-, and tri-meric imidazolium salts in high yields. Subsequent anion-exchange reactions produced compounds with yields of 83-89%, while solid-phase, silica-supported processes further enhanced yields to 89-96%. The antibacterial activity of these compounds against six human pathogens (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus vulgaris, Staphylococcus aureus, and Enterococcus faecalis) was evaluated using well diffusion and broth microdilution techniques. Not

SUBMITTER: Ganapathi P 

PROVIDER: S-EPMC12459267 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature