14-3-3 proteins: Regulators of cardiac excitation-contraction coupling and stress responses.

ABSTRACT: 14-3-3 proteins are highly conserved proteins that regulate numerous cellular processes mostly through phosphorylation-dependent protein-protein interactions. In the heart 14-3-3 proteins play critical roles in cardiac conduction pathways, excitation-contraction (EC) coupling, development and stress responses. This review summarizes the current understanding of cardiac 14-3-3 regulation and function, with particular emphasis on its role in ion channel regulation and β-adrenergic signalling. We discuss how 14-3-3 proteins act through three main mechanisms - masking, clamping, and scaffolding - to regulate target proteins, including Cx43, Ca_V1.2, Na_V1.5, and various potassium channels. The seven mammalian 14-3-3 isoforms display distinct but overlapping functions, with

SUBMITTER: Spooner HC 

PROVIDER: S-EPMC12459269 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature