Greater large conducting airway luminal area in adult patients with interstitial lung disease.

ABSTRACT: Interstitial lung disease (ILD) encompasses pulmonary disorders characterized by chronic inflammation and fibrosis that disrupt pulmonary gas exchange. While ILD-related changes in the lung parenchyma are well-documented, less is known about how ILD affects luminal area within the large conducting airways. This retrospective, case-control study tested the hypothesis that patients with ILD would have greater large conducting airway luminal areas than healthy matched controls. Three-dimensional reconstructions of computed tomography images were used to quantify airway luminal areas in patients with ILD (n = 82; 54% female) and healthy controls matched for age, sex, and height. Patients with ILD had 16%-22% greater airway luminal areas across all seven measured large conducting airways compar

SUBMITTER: Miller AJ 

PROVIDER: S-EPMC12459309 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature