MoSec13 combined with MoGcn5b modulates MoAtg8 acetylation and regulates autophagy in <i>Magnaporthe oryzae</i>.

ABSTRACT: Macroautophagy/autophagy is an evolutionarily conserved cellular degradation process that is crucial for cellular homeostasis in Magnaporthe oryzae. However, the precise regulatory mechanisms governing autophagy in this organism remain unclear. In this study, we found a multiregional localization of MoSec13 to the vesicle membrane, endoplasmic reticulum, nucleus, and perinucleus. MoSec13 negatively regulated autophagy through specific amino acid residues in its own WD40 structural domain by interacting with MoAtg7 and MoAtg8. We also found that the histone acetyltransferase MoGcn5b mediated the acetylation of MoAtg8 and regulated autophagy activity. Subsequently, we further determined that MoSec13 regulated the acetylation status of MoAtg8 by controlling the interaction between MoGc

SUBMITTER: Qian H 

PROVIDER: S-EPMC12459355 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature