Altered Ventilation in Rats With Established Severe Monocrotaline-Induced Pulmonary Hypertension: The Role of the Dorsal Hypothalamus.

ABSTRACT: Pulmonary hypertension (PH) is a progressive condition characterized by muscularization of precapillary arteries, chronic inflammation, and a loss of the distal pulmonary circulation. These changes can be mimicked in rats by monocrotaline (MCT) administration. The impact of MCT-induced pulmonary damage on ventilatory control is poorly understood. In this study, we investigated whether the severity of PH induced by MCT in rats is linked to ventilatory changes. We examined ventilatory variables in awake (plethysmographic) and anesthetized (tracheal) rats, stratified by disease severity (Fulton's index). Two subgroups were identified: mild (Fulton's index < 0.49) and severe (Fulton's index > 0.53) PH. Resting ventilation was significantly increased in severe but not mild PH rats compared to c

SUBMITTER: Le Pape A 

PROVIDER: S-EPMC12459422 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature