Analyzing the causal relationship between gut microbiota, metabolites, and constipation: A Mendelian randomization study.

ABSTRACT: A growing body of evidence suggests that the gut microbiota (GM) and its metabolites may play a role in the development of constipation; however, further investigation is necessary to ascertain the precise relationship. Genetic instruments were derived from large-scale genome-wide association studies (GWAS) of European populations. Pooled summary statistics for GM (n = 18,340) and metabolites (n = 7824) were derived from public GWAS, while constipation data (n = 47,696) were obtained from the FinnGen database R10. Mendelian randomization (MR) analyses were performed using data from GWAS to determine a causal association between GM, metabolites, and constipation. Sensitivity analyses were performed to assess the robustness of the MR results, and reverse MR analyses were performed to determi

SUBMITTER: He M 

PROVIDER: S-EPMC12459447 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature