Proteome-wide Mendelian randomization and colocalization analysis identify therapeutic targets for cutaneous melanoma.

ABSTRACT: Cutaneous melanoma (CM) is the deadliest form of skin cancer, posing a significant threat to human health. In the ongoing efforts to develop effective treatments, identifying novel therapeutic targets is crucial. This research aimed to use Mendelian randomization and colocalization analysis to discover plasma proteins that could serve as new therapeutic targets for CM, while also assessing the potential adverse effects associated with these targets. The study harnessed plasma protein data from the UK Biobank Pharmaceutical Proteomics Project database, which contained genome-wide association data for 2940 proteins. These data were integrated with CM data from the Finnish database, involving 3194 patients and 314,193 controls. Proteome-wide analysis was then conducted to explore the associat

SUBMITTER: Zhou D 

PROVIDER: S-EPMC12459469 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature