Associations between allergic diseases and autoimmune thyroid diseases: A meta-analysis of Mendelian randomization studies.

ABSTRACT: Both allergic and autoimmune thyroid disorders (AITD) exhibit a high prevalence and a low cure rate, but their relationship remained debated. Therefore, bidirectional Mendelian randomization (MR) method and cross-phenotype association analysis (CPASSOC) were used to investigate the correlation between 2 diseases. Genome-wide association studies (GWAS) data was used as genetic instruments, followed by performing linkage disequilibrium score regression (LDSC) analysis. We have utilized the bidirectional MR method to examine the mutual association between allergic asthma (AA), allergic rhinitis (AR), urticaria, and Graves' disease (GD), autoimmune thyroiditis (AIT). In addition, the false discovery rate (FDR) was carried out to control the false positive results. After synthesizing all the re

SUBMITTER: Li J 

PROVIDER: S-EPMC12459506 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature