Causal effects of sedentary behavior and physical activity on the risk of musculoskeletal disorders: Evidence from Mendelian randomization analysis.

ABSTRACT: Previous studies have noted the associations of sedentary behavior and physical activity with several musculoskeletal disorders (MSDs), yet the causality of these relationships remains unclear. In this study, we probed into the causal associations between sedentary behavior, physical activity, and the risk of 13 MSDs through Mendelian randomization (MR) analysis. We obtained summary statistics for leisure screen time (LST) and moderate-to-vigorous intensity physical activity (MVPA) from genome-wide association studies (GWAS) for 2-sample univariable MR analysis. The linkage disequilibrium score regression (LDSC) was used for genetic correlation analysis. Multivariable MR analysis was conducted on LST and MVPA to adjust for one another. Furthermore, we performed mediation analysis to reveal

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12459519 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature