A Mendelian randomization study: Genetically predicted dopamine 4-sulfate to dopamine 3-O-sulfate ratio mediates the association between chemokine C-C motif ligand 11 and polycystic ovary syndrome.

ABSTRACT: This Mendelian randomization (MR) study aims to elucidate the causal pathways between circulating chemokine C-C motif ligand 11 (CCL11) levels and the pathogenesis of polycystic ovary syndrome (PCOS), with a specific focus on the mediating role of dopamine sulfate isomers. Using genome-wide association data from 14,824 European participants (for CCL11 quantitative trait loci) and 2,01,005 individuals (including 1424 PCOS cases), we performed 2-sample MR analyses, with inverse-variance weighting as the primary estimator. Sensitivity analyses included MR-Egger regression and weighted median approaches. Genetic predisposition to elevated CCL11 concentrations was significantly associated with an increased risk of PCOS (odds ratio = 1.28 per standard deviation increase, 95% confidence interval

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12459524 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature