The causal relationship between 91 inflammatory cytokines and chronic pancreatitis, and the mediating role of 1400 metabolites.

ABSTRACT: Considerable amounts of studies have confirmed a close relationship between specific inflammatory cytokines and chronic pancreatitis (CP), while the causal effect between the 2 remains unclear. This study is to evaluate the causal relationship between 91 inflammatory cytokines and CP using bidirectional 2-sample Mendelian randomization (MR) method, and to investigate the mediating role of 1400 metabolites through a 2-step MR analysis. Genome wide association study (GWAS) data related to 91 inflammatory cytokines were sourced from 14,824 participants of European populations, and CP related GWAS data from a Finnish database, covering 3875 cases of CP cases and 361,641 controls. A total of 1400 circulating metabolites were derived from 8299 individuals. This study used inverse variance weight

SUBMITTER: Yang C 

PROVIDER: S-EPMC12459525 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature