Causal Mediation Analysis for Integrating Exposure, Genomic, and Phenotype Data.

ABSTRACT: Causal mediation analysis provides an attractive framework for integrating diverse types of exposure, genomic, and phenotype data. Recently, this field has seen a surge of interest, largely driven by the increasing need for causal mediation analyses in health and social sciences. This article aims to provide a review of recent developments in mediation analysis, encompassing mediation analysis of a single mediator and a large number of mediators, as well as mediation analysis with multiple exposures and mediators. Our review focuses on the recent advancements in statistical inference for causal mediation analysis, especially in the context of high-dimensional mediation analysis. We delve into the complexities of testing mediation effects, especially addressing the challenge of testing a la

SUBMITTER: Yang H 

PROVIDER: S-EPMC12459592 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature