Causal relationship between 179 plasma lipids and intracranial aneurysm: A 2-sample Mendelian randomization study.

ABSTRACT: Current evidence suggests that the deposition of lipid plaques is frequently observed in the walls of intracranial aneurysms (IAs). Therefore, the objective of this research was to determine the causal link between plasma lipids and IAs. Genetic instrumental variables for 179 plasma lipids were acquired from a genome-wide association study of 7174 unrelated Finnish individuals. Outcome data for individuals with IAs were retrieved from a genome-wide association study involving 23 cohorts, comprising 79,429 individuals of European ancestry. An inverse-variance weighted method was employed as the key analysis method. To ensure the reliability of the findings, Mendelian randomization (MR)-Egger regression, weighted-median, and weighted-mode methods were employed. Sensitivity analyses included

SUBMITTER: Ding L 

PROVIDER: S-EPMC12459603 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature