A rapid method for phosphocreatine-weighted imaging in muscle using double saturation power-chemical exchange saturation transfer.

ABSTRACT: Monitoring the variation in phosphocreatine (PCr) levels following exercise provides valuable insights into muscle function. Chemical exchange saturation transfer (CEST) has emerged as a sensitive method with which to measure PCr levels in muscle, surpassing conventional MR spectroscopy. However, existing approaches for quantifying PCr CEST signals rely on time-consuming fitting methods that require the acquisition of the entire or a section of the CEST Z-spectrum. Additionally, traditional fitting methods often necessitate clear CEST peaks, which may be challenging to obtain at low magnetic fields. This paper evaluated the application of a new model-free method using double saturation power (DSP), termed DSP-CEST, to estimate the PCr CEST signal in muscle. The DSP-CEST method requires the

SUBMITTER: Viswanathan M 

PROVIDER: S-EPMC12459672 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature