Clinical characteristics, risk factors and outcome of critically ill immunocompromised patients with bloodstream infections and sepsis.

ABSTRACT:

Background

Immunocompromised patients with sepsis face higher mortality than immunocompetent individuals. However, data on bloodstream infections (BSIs) and sepsis among critically ill immunocompromised (CII) patients remain limited. We aimed to describe the epidemiology, outcomes, and mortality risk factors of BSIs in this population.

Methods

We conducted a retrospective cohort study of CII patients admitted to the medical ICU between January 2022 and December 2023 with suspected sepsis or septic shock. Patients with BSIs confirmed by positive blood cultures were identified. Propensity score matching (1:1) without replacement was used to create comparable groups for Cox regression analysis of 30-day all-cause mortality.

Results

Among 211 CII patients (mean age (SD) 6

SUBMITTER: Vonineng N 

PROVIDER: S-EPMC12459766 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature