The Connectional Diaschisis and Normalization of Cortical Language Network Dynamics After Basal Ganglia and Thalamus Stroke.

ABSTRACT: Stroke affecting the basal ganglia and thalamus can lead to language deficits. In addition to the lesion's direct impact on language processing, connectional diaschisis involving cortical-subcortical interactions also plays a critical role. This study investigated connectional diaschisis using the dynamic meta-networking framework of language in patients with basal ganglia and thalamus stroke, analyzing longitudinal resting-state fMRI data collected at 2 weeks (n = 32), 3 months (n = 19), and 1 year post-stroke (n = 23). As expected, we observed dynamic cortico-subcortical interactions between cortical language regions and subcortical regions in healthy controls (HCs; n = 25). The cortical language network exhibited dynamic domain-segregation patterns in

SUBMITTER: Chen Q 

PROVIDER: S-EPMC12459977 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature