Local and systemic immunological response in feline chronic gingivostomatitis: a critical review.

ABSTRACT:

Introduction

A comprehensive understanding of the oral immune response in feline chronic gingivostomatitis (FCGS) is crucial for veterinarians to improve clinical and therapeutic decisions. This critical review addresses the local and systemic immune responses associated with FCGS.

Methods

A comprehensive database search was conducted using the PubMed/MEDLINE database, resulting in 3,358 studies. Following a rigorous screening process, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, 17 publications were included in this review.

Results

The local immune response in FCGS is primarily evaluated through histopathological and immunohistochemical analyses of oral biopsy samples, and by analysis of saliva. Histop

SUBMITTER: Lopes RS 

PROVIDER: S-EPMC12460127 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature