Association between MTHFR polymorphisms and vitamin D status in infertile women: a mediation analysis.

ABSTRACT:

Background

Methylenetetrahydrofolate reductase (MTHFR) regulates folate metabolism and homocysteine (Hcy) methylation. Impaired folate metabolism and vitamin D deficiency are both closely associated with female reproductive disorders, but their specific roles and relationship remain largely unknown. This study aimed to investigate the relationship between MTHFR polymorphisms and vitamin D status and to examine the mediating effect of Hcy.

Methods

A total of 6,344 infertile patients were included in this retrospective study. Multivariable logistic regression and multiple linear regression models, and stratified analyses were used to investigate the relationship between MTHFR polymorphisms (C677T and A1298C) and vitamin D status. Smooth curve fitting model and spearman correla

SUBMITTER: Zhou R 

PROVIDER: S-EPMC12460134 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature