Catalytic enantioselective synthesis of alkylidenecyclopropanes.

ABSTRACT: The enantioselective construction of small-ring carbocycles provides organic chemists with an enduring challenge¹. Despite their commercial importance, enantioselective synthetic routes towards alkylidenecyclopropanes, a class of small-ring carbocycles, remain underdeveloped^2,3. Alkylidenecyclopropanes can be converted into cyclopropanes, a common feature in drug molecules (for example, Nirmatrelvir 1)⁴, as well as both naturally occurring and synthetic agrochemicals (for example, permethrin 2)^5,6. Here we describe the facile synthesis of highly enantioenriched alkylidenecyclopropanes through the use of a bifunctional iminophosphorane catalysed, stereo-controlled, strain-relieving deconjugation. Small modifications to the basic catalyst system we

SUBMITTER: Golec JC 

PROVIDER: S-EPMC12460155 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature