Structural basis of fast N-type inactivation in K_v channels.

ABSTRACT: Action potentials are generated by opening of voltage-activated sodium (Na_v) and potassium (K_v) channels¹, which can rapidly inactivate to shape the nerve impulse and contribute to synaptic facilitation and short-term memory^1-4. The mechanism of fast inactivation was proposed to involve an intracellular domain that blocks the internal pore in both Na_v^5,6 and K_v^7-9 channels; however, recent studies in Na_v^10,11 and K_v^12,13 channels support a mechanism in which the internal pore closes during inactivation. Here we investigate the mechanism of fast inactivation in the Shaker K_v channel using cryo-electron microscopy, mass spectrometry and electrophysiol

SUBMITTER: Tan XF 

PROVIDER: S-EPMC12460158 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature