Comparison of the vitamin D level between children with and without cow's milk protein allergy: a systematic review with meta-analysis.

ABSTRACT:

Background

Vitamin D plays an important role in modulating immune responses, which may be associated with cow's milk protein allergy (CMPA). This meta-analysis aimed to comprehensively compare the vitamin D level between children with CMPA and healthy controls.

Methods

Studies comparing the vitamin D level between children with CMPA and healthy controls were comprehensively searched in PubMed, Web of Science, Embase, Wan Fang, CNKI, and VIP until April 2025.

Results

A total of 12 studies, involving 605 children with confirmed CMPA (CMPA group) and 558 healthy controls (control group) were included. The vitamin D level was lower in the CMPA group than in the control group [standardized mean difference (SMD) (95% confidence interval): -1.229 (-2.117, -0.340), P =

SUBMITTER: Zheng X 

PROVIDER: S-EPMC12460241 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature