Criteria for defining and dating onset of organ system involvement in systemic sclerosis.

ABSTRACT:

Objectives

This study was undertaken to develop standardized definitions of individual organ system involvement in systemic sclerosis and their date of onset, with the overall goal of increasing the internal validity and comparability of future clinical trials and observational studies.

Methods

Under the auspices of the Scleroderma Clinical Trials Consortium, an international working group of experts and patient partners formed nine sub-groups for each of the following organ systems: skin, peripheral vascular, joints/tendons, skeletal muscle, gastrointestinal tract, parenchymal lung, pulmonary arterial hypertension, heart, and kidney. Lists of elements that could be considered as potential criteria for involvement of each organ system were compiled. A three-round Delphi exer

SUBMITTER: Hudson M 

PROVIDER: S-EPMC12460267 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature