Postural orthostatic tachycardia syndrome in post-COVID-19 long-hauler patients is associated with platelet storage pool deficiency.

ABSTRACT:

Introduction

Postural orthostatic tachycardia syndrome (POTS), a type of dysautonomia, has been an enigma to many healthcare providers. As many as 80% of coronavirus disease 2019 (COVID-19) long-hauler patients meet the diagnostic criteria for POTS, highlighting awareness of this debilitating multisystem disorder. The etiology of POTS has not been entirely defined, but researchers have speculated that an immunological stressor such as a viral infection might be an initiating event. Prior to the pandemic, we reported that POTS patients have a bleeding diathesis with platelet dense granule storage pool deficiency (δ-SPD).

Methods

This report presents a prospective case-control study (n = 252) involving four cohorts, comprising two groups of POTS patients and two groups

SUBMITTER: Gunning WT 

PROVIDER: S-EPMC12460298 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature