Load-bearing aerobic exercise prior to injury moderates systemic immunosuppression response to fracture.

ABSTRACT: Bone fracture non-unions are common and often lead to costly revision surgeries, long-term patient pain and loss of function. Identifying fractures at-risk for non-union remains challenging due to an incomplete understanding of underlying mechanisms. Preclinical and clinical studies have shown that dysregulated immune responses are linked to impaired healing. These studies have also identified fracture characteristics, biologic factors, and lifestyle habits associated with a higher risk of poor healing. However, the impact of exercise history on the immune response to fracture remains underexplored. Load-bearing aerobic exercise is known to modulate properties of bone and systemic inflammation, suggesting that exercise history could influence post-fracture immune responses and healing outc

SUBMITTER: Strait LK 

PROVIDER: S-EPMC12460303 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature