The Tryptophan-Kynurenine pathway in people living with HIV: a systematic review.

ABSTRACT:

Purpose

HIV-1 disrupts the metabolic profile of people living with HIV (PLWH), including the Tryptophan-Kynurenine (Trp-Kyn) pathway, linked to disease outcomes and comorbidities. Despite numerous studies, consensus on key dysregulated metabolites in antiretroviral therapy (ART)-treated PLWH is lacking. This systematic review compiles data to identify and highlight the most noteworthy Trp-Kyn metabolites.

Methods

PubMed, Scopus, and Web of Science databases were searched using a search protocol specifically designed for this study. Studies that investigated the levels of metabolites in the Trp-Kyn pathway in the peripheral blood of PLWH on ART, as well as in healthy control groups were included.

Results

Thirteen metabolomic studies that investigated this pathway met o

SUBMITTER: Sebigi TW 

PROVIDER: S-EPMC12460365 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature