Intra-articular Hyaluronic Acid Injections May Be Beneficial in Patients with Less Advanced Knee Osteoarthritis: A Systematic Review of Randomised Controlled Trials.

ABSTRACT:

Background

Knee osteoarthritis is a degenerative joint disease that impairs quality of life. Hyaluronic acid (HA) injections are used to restore synovial fluid viscosity and improve joint function.

Objectives

The present systematic review investigated the prognostic factors influencing the effect of intra-articular HA injections for knee osteoarthritis (OA). The endpoint of interest was whether patient characteristics and molecular weight of the HA influence patient-reported outcome measures (PROMs) at different follow-ups.

Methods

This study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the 2020 PRISMA statement. All randomised controlled trials (RCTs) investigating the efficacy of intra-articular HA injections in

SUBMITTER: Migliorini F 

PROVIDER: S-EPMC12460378 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature