Model-informed identification of optimised dosing strategies for meropenem in critically ill patients receiving SLEDD: an observational study.

ABSTRACT:

Purpose

An increasing number of critically ill patients receive slow extended daily dialysis (SLEDD) due to their pathophysiology while suffering from sepsis, necessitating effective and safe antibiotic therapy. Although SLEDD reduces meropenem exposure and increases treatment failure risk, effective and safe dosing regimens are unclear. We aimed to identify optimised meropenem dosing strategies for critically ill SLEDD patients through population pharmacokinetic (PK) modelling and PK/pharmacodynamic (PD)-based probability of target attainment (PTA) analysis.

Methods

Clinical data from a prospective study involving critically ill SLEDD patients receiving meropenem were monitored through routine therapeutic drug monitoring. A total of 178 blood samples from 13 patients (media

SUBMITTER: Weber F 

PROVIDER: S-EPMC12460387 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature