Mutant mouse models implicate a role for mGluR1/5, prolyl isomerase (Pin1) and Homer1a interactions in wakefulness.

ABSTRACT:

Introduction

Healthy sleep and wake are integral to good health and occur when an organism is able to maintain long bouts of both sleep and wakefulness. Homer proteins have been shown to be important for sleep in both Drosophila and mice. For example, genetic deletion of Homer1a in mice results in failure to sustain long bouts of wakefulness. Homer1a has also been shown to amplify mGluR activity by facilitating binding of the prolyl isomerase Pin1 to mGluR. This study uses mouse models to evaluate whether the Homer1a null sleep phenotype may be dependent on the mGluR-Pin1 interaction and examines sleep/wake behavior.

Methods

EEG recordings were used to determine and compare sleep and wake in three different mouse models and their littermate control mice.

SUBMITTER: Keenan BT 

PROVIDER: S-EPMC12460416 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature