Microbiological diversity among patients with Lemierre syndrome and clinical implications: an individual patient-level analysis.

ABSTRACT:

Purpose

Lemierre syndrome is a rare condition traditionally defined by bacterial infection of the head/neck region, local thrombophlebitis, and septic embolism. Although in most cases Fusobacterium necrophorum is isolated, it is questionable whether the presence of this microbe is mandatory for diagnosis. In this study, we investigated microorganisms isolated in cases of Lemierre syndrome and their association with demographical and clinical features.

Methods

We conducted an analysis of individual patient data from 712 patients diagnosed with Lemierre syndrome. Demographics, clinical presentation, treatment strategies, and outcomes according to different pathogens were evaluated.

Results

Among a total of 712 patients, in 574 cases bacterial growth was detected. In 415

SUBMITTER: Frehner M 

PROVIDER: S-EPMC12460448 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature