Hematological characteristics, oxidative stress, and patient-reported symptoms in Tibetan patients with chronic mountain sickness at 4500 m altitude.

ABSTRACT:

Background

Chronic mountain sickness (CMS), driven by chronic hypoxia, features erythrocytosis, cardiovascular impairment, and systemic oxidative stress. Current studies focus on haematological and cardiopulmonary changes, but multidimensional features like sleep disturbances, quality of life, and oxidative stress remain underexplored.

Methods

The cross-sectional study included 47 adult Tibetan residents living at 4,500 m and diagnosed with CMS using Qinghai criteria. Blood samples were collected, and questionnaires assessed quality of life, fatigue, and sleep. Multivariate logistic regression was used to explore associations between variables, using CMS comorbid with high-altitude polycythemia (HAPC) or sleep disturbance as endpoints.

Results

The mean age of patients

SUBMITTER: Zhong Y 

PROVIDER: S-EPMC12460463 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature