Effect of FRAXplus adjustments on fracture risk reclassification in older Swedish women-results from the SUPERB-study.

ABSTRACT: FRAXplus® facilitates adjustment of FRAX® fracture probabilities for additional clinical risk factors. This study examined how FRAXplus adjustments affect the proportion of older Swedish women eligible for treatment at a major osteoporotic fracture (MOF) probability intervention threshold (IT) ≥ 26%.

Background

FRAXplus enables adjustments based on additional clinical information, such as recency of osteoporotic fractures, high-dose oral glucocorticoids, T2DM duration, lumbar spine (LS) bone mineral density (BMD), trabecular bone score (TBS), falls in the previous year, and hip axis length. We aimed to determine how these adjustments alter treatment eligibility in older Swedish women.

Methods

Ten-year fracture probabilities with femoral neck BMD were calculated using FRAX and

SUBMITTER: Zoulakis M 

PROVIDER: S-EPMC12460473 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature