A simple clinical tool for effective screening of haemophagocytic lymphohistiocytosis in dengue.

ABSTRACT:

Purpose

Haemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening disorder. Dengue fever is a common trigger for HLH in the tropics. We aimed to develop a simplified clinical tool to detect HLH in dengue patients.

Methods

A cross-sectional observational study was carried out at Kasturba Medical College Mangalore. Patients between 18 and 60 years of age, with dengue fever for more than five days with suspected HLH symptoms were selected. Hepatosplenomegaly, temperature, haemoglobin levels, total leucocyte count, platelet count, ferritin, triglyceride, and liver function tests were assessed. HLH-2004 criteria were used to confirm the diagnosis. A simple clinical tool was developed via decision tree analysis using clinical and laboratory parameters.

Results

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SUBMITTER: Kuttykandathil JJ 

PROVIDER: S-EPMC12460484 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature