Malignancy in Adults with Inborn Errors of Immunity: A Retrospective Single-Center Study.

ABSTRACT:

Purpose

Inborn Errors of Immunity (IEI) often lead to recurrent infections, immune dysregulation, and an increased risk of malignancies. Due to the heterogeneity in IEI presentations, personalized monitoring is essential for early detection of non-infectious complications. This study aims to document the characteristics and prevalence of malignancies in IEI patients.

Methods

A retrospective review of 355 patients diagnosed with IEI at the Adult Allergy and Immunology Clinic of Ege University was conducted. Data on demographics, clinical presentations, laboratory results, and immunological and genetic profiles of patients with malignancies were analyzed.  RESULTS: A total of 40 patients with neoplasia (F/M: 18/22; median age: 51.58 years, range: 18-91) were evaluated. The med

SUBMITTER: Gumusburun R 

PROVIDER: S-EPMC12460494 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature