Efficacy and safety of analgosedation with dexmedetomidine in critically ill mechanically ventilated children: a systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Objective

Dexmedetomidine is an increasingly popular analgosedative in critically ill children receiving invasive mechanical ventilation (IMV). We conducted a systematic review to evaluate the efficacy of dexmedetomidine compared to other analgosedatives in this population.

Data sources

Seven electronic databases and trial registries to July 2024, without language restrictions.

Study selection

Randomized controlled trials comparing dexmedetomidine to other analgosedatives in critically ill children receiving IMV.

Data extraction and synthesis

Independently and in duplicate, we conducted data extraction, risk of bias assessment, and certainty assessment using Grading of Recommendations, Assessment, Development, and Evaluation. We conducted random-effects meta-an

SUBMITTER: Zorko DJ 

PROVIDER: S-EPMC12460513 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature