Clinical impact of bronchoalveolar lavage fluid metagenomic next-generation sequencing in immunocompromised patients with severe community-acquired pneumonia in ICU: a multicenter retrospective study.

ABSTRACT:

Background

An increasing number of critically ill patients are immunocompromised. These patients are at high risk of intensive care unit (ICU) admission because of numerous complications. Acute respiratory failure due to severe community-acquired pneumonia (SCAP) is one of the leading causes of admission. Early targeted antibiotic therapy is crucial for improving the prognosis of these patients. Metagenomic next-generation sequencing (mNGS) in bronchoalveolar lavage fluid (BALF) has shown significant value in pathogen detection in recent years. However, there are few studies on summarizing pathogen profiles of SCAP in immunocompromised patients.

Methods

We performed a multicenter retrospective analysis of patients with SCAP in the ICU diagnosed between May 2021 to October 20

SUBMITTER: Zhao J 

PROVIDER: S-EPMC12460554 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature