Vascular function in patients with advanced heart failure and continuous-flow or pulsatile ventricular assist devices.

ABSTRACT:

Background

A significant proportion of patients with heart failure (HF) progress to an advanced stage, which is associated with a substantial increase in morbidity and mortality. These patients may be eligible for advanced treatment strategies such as mechanical circulatory support with ventricular assist devices (VAD). Vascular dysfunction is a hallmark of heart failure pathophysiology and prognosis. However, whether and to what degree the hemodynamic benefits of VADs influence vascular function remain unknown.

Methods and results

In this study, we evaluated endothelial vascular function with flow-mediated vasodilatation (FMD) and with flicker-light induced retinal vasodilatation (FID). 34 patients with a VAD (age 58 ± 10 years, 85% male, 74% ischemic heart disease, 26 cont

SUBMITTER: Rossi VA 

PROVIDER: S-EPMC12460578 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature