Evaluation of a DNA methylation-based measure of chronic inflammation in two generations of adults in metropolitan Cebu, Philippines.

ABSTRACT: Proxy measures of chronic inflammation derived from DNA methylation (DNAm) data have emerged as promising predictors of cardiometabolic disease in high income countries. The performance of these measures in lower and middle income settings experiencing higher levels of endemic infections as well as rising rates of chronic degenerative diseases is not known. A DNAm-based proxy for C-reactive protein (DNAm-CRP) was calculated from 1468 CpG sites on the Infinium MethylationEPIC v1.0 array applied to genomic DNA from leukocytes in young adults (N = 1665; 20-22 years) and older women (N = 1070; 35-68 years) in the Philippines. CRP was determined in plasma using a high sensitivity immunoturbidimetric assay. Pearson correlation and least squares regression were implemented to evaluate the strengt

SUBMITTER: McDade TW 

PROVIDER: S-EPMC12460616 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature