Design and synthesis of novel small molecules targeting the Kv1.3 voltage-gated potassium ion channel.

ABSTRACT: Autoimmune diseases (ADs) affect almost 10% of the world population. They are also the leading cause of mortality among young and middle-aged women. Despite the available of therapeutic agents there is no definitive cure. The voltage-gated potassium channel (Kv1.3) plays a key role regulating various physiological processes, particularly immune responses, making it a promising target for immunomodulators. Moreover, the ability of Kv1.3 blockers to selectively modulate the activation of effector memory T-cells, without affecting other lymphoid subsets, make it a promising target to avoid fatal opportunistic infections encountered with broad spectrum immunosuppressants. Herein, a β-carboline-based lead (KMA) was developed through ligand-directed scaffold hopping based on the known Kv1.3 inhi

SUBMITTER: Abdelwaly A 

PROVIDER: S-EPMC12460622 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature