In silico reconstructions underpin aberrant trafficking dynamics in deficient axons of Dst knockout and Dst/Nefl double-knockout mice.

ABSTRACT: Aberrant neuronal trafficking is a significant hallmark of neurodegenerative pathology. Its real-time evolution remains elusive and poorly defined due to the lack of a predictive spatiotemporal framework. Building upon a general neurocytoskeletal-PDEs (iGCPs) model, we propose the concept of Virtual Cellular Dynamics for quantitative spatiotemporal simulations of mitochondrial dynamics within axons. The model integrates interactions of key cytoskeletal components such as dystonin, microtubule, neurofilament, and actin filament, providing a comprehensive framework for neuron-specific virtual cell modeling, enabling quantitative insight into axonal dysfunction and structural degradation across neurodegenerative disease. Not only does our model recapitulate the significant structural deformat

SUBMITTER: Liu Z 

PROVIDER: S-EPMC12460766 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature