Depolarization block induction via slow Na_V1.1 inactivation in Dravet syndrome.

ABSTRACT: Dravet syndrome is a developmental and epileptic encephalopathy, characterized by the early onset of drug-resistant seizures and various comorbidities. Most cases of this severe and complex pathology are due to mutations of Na_V1.1, a sodium channel mainly expressed in fast-spiking inhibitory neurons. Layer et al. (Front. Cell. Neurosci. 15, 2021) showed that one of these mutations alters the voltage dependence of channel activation, as well as the voltage dependence and kinetics of slow inactivation. Implementing the three effects into a computational model, they predict that altered activation has the largest impact on channel function, as it causes the most severe firing rate reduction. Using a conductance-based model tailored to the dynamics of fast-spiking inhibitory neurons

SUBMITTER: Lemaire L 

PROVIDER: S-EPMC12460796 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature