Causal effects of circulating inflammatory proteins on colorectal cancer: a Mendelian randomization and Spatial transcriptomic study.

ABSTRACT:

Objective

This study aimed to investigate the potential causal relationships between 91 circulating inflammatory proteins and colorectal cancer (CRC) using a two-sample bidirectional Mendelian randomization (MR) framework, supplemented by spatial transcriptomic analysis.

Methods

Genetic instruments for circulating inflammatory proteins were obtained from genome-wide association studies (GWAS) involving individuals of European ancestry. CRC outcome data were sourced from BioBank Japan. The inverse variance weighted (IVW) method was used as the primary analytical approach, complemented by MR-Egger regression, weighted median, and mode-based estimators. Horizontal pleiotropy and heterogeneity were assessed using the MR-Egger intercept, Mendelian Randomization Pleiotropy RESidua

SUBMITTER: Bai M 

PROVIDER: S-EPMC12460858 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature