UK Biobank study of the association between circadian syndrome and cardio-kidney events or all-cause mortality.

ABSTRACT:

Background

Circadian syndrome (CircS) has demonstrated a strong association with the occurrence of cardiovascular disease (CVD), as well as chronic kidney disease (CKD). However, the association of CircS with cardiac-kidney events (CKE) or even mortality is unknown. This study was to evaluate whether CircS was related with CKE or all-cause mortality.

Methods

This prospective study analyzed data from 295,378 participants in the UK Biobank (UKB) cohort. CircS was characterized by the components of metabolic syndrome (MetS), along with short sleep and depression. We applied Cox regression analyses to examine the associations between CircS and composite outcome of CKE or all-cause mortality.

Results

Among the 295,378 included participants (median age, 58 years; 55.7% fema

SUBMITTER: Yang HJ 

PROVIDER: S-EPMC12460872 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature