Fibre supplementation alters the gastrointestinal microbiome, the microbial metabolites and indicators of neurodegeneration in a mouse model of Alzheimer´s disease.

ABSTRACT: Alzheimer´s disease is a neurodegenerative disease with high global prevalence and no cure available. It is known that the microbiota-gut-brain-axis plays a role in the pathogenesis, but the pathways are not fully understood yet. To elucidate the role of dietary fibre supplementation on this axis in a 5xFAD mouse model of Alzheimer´s disease, a feeding trial with an inulin supplement was conducted. At the start (Basis, n = 11) and after 7 weeks with (AD + F; n = 15) and without (AD; n = 15) supplementation, the mice were sacrificed and the following samples were taken: ingesta for 16 S rRNA sequencing and short-chain fatty acid (SCFA) analysis, and brain tissue for amyloid-beta staining and proteome analysis. The microbiota patterns in stomach, small intestine, caecum and colon differed be

SUBMITTER: Boswald LF 

PROVIDER: S-EPMC12460888 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature