Early Versus Late Dialysis in Cirrhosis Patients and Septic Shock (ELDICS Study): A Randomized Controlled Trial (NCT02937961).

ABSTRACT:

Background and aim

Critically ill cirrhotics (CIC) pose a management challenge due to severe metabolic and renal impairment. The ideal timing of initiation of dialysis in acute kidney injury (AKI) in CIC is not known. We aimed to compare the safety and efficacy of early (ED) versus late (LD) initiation of sustained low-efficiency dialysis (SLED) in CIC.

Methods

CIC were randomized to ED (SLED initiated within 6-12 h) or the LD (where SLED was performed when the patient met absolute criteria) group.

Results

Fifty CIC (aged 45.2 ± 10 years), 90% males, 87% alcohol-related, 72% with pneumonia admitted to liver ICU were randomized to ED or LD group. Baseline lactate (mg/dL) (2.7 ± 1.8 vs. 3.3 ± 2.1) and SOFA scores (12.9 ± 2.1 vs. 13.7 ± 4.0) were comparable. Median time

SUBMITTER: Maiwall R 

PROVIDER: S-EPMC12460919 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature