Nerve Fibres in Psoriatic Skin and Their Relation to Vasculature and Clinical Parameters.

ABSTRACT: Emerging evidence supports the neurogenic origin of psoriasis, yet the morphology and distribution of nerve fibres in psoriatic skin remain poorly characterised due to methodological inconsistencies and limited 3D data. The aim of this study was to provide a comprehensive 3D quantification of nerve fibre morphology in psoriatic skin and assess its spatial relation to vasculature and clinical parameters. High-resolution confocal microscopy was used to analyse 69 (70 μm thick) skin sections from 23 psoriasis patients, capturing full-thickness epidermis and dermis. Nerve fibres were segmented by location (epidermal, papillary and reticular) and quantified volumetrically alongside vascular networks. The results show that nerve fibres occupied ~0.1% of total skin volume and predominantly locali

SUBMITTER: Doppegieter M 

PROVIDER: S-EPMC12460965 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature